Comparison of simple canalith repositioning treatment and medication therapeutic alliance in the management of canalithiasis associated with benign paroxysmal positional vertigo of the horizontal semicircular canal / 临床耳鼻咽喉头颈外科杂志

Objective:To compare the therapeutic efficacy and the recurrence rate between the simple repositioning method and the reposition manoeuvre plus medication in the treatment of horizontal semicircular canal otolith benign paroxysmal positional vertigo (HSC-BPPV). Method:Sixty-two patients diagnosed with otolith HSC-BPPV by roll maneuver test were randomly divided into canalith repositioning group (32 patients) and reposition plus drug treatment group (30 patients). Patients in the canalith repositioning group were treated only with Barbecue reposition maneuver; patients in the reposition plus drug treatment group were treated firstly with Barbecue reposition maneuver and then were given Alprostadil, Cinepazide and Betahistine drug treatment. Both groups were evaluated after 7 days and 28 days treatment, and the recurrence rate was analyzed after 3 months. Result:After 7 days of the treatment , the recovery rate of the two groups was 62.5% and 73.3%, respectively. There's no significant difference between the two groups. However, the total effective power of the reposition plus drug treatment group was 96.7%, which was significantly higher than that of the canalith repositioning group (75.0%) (χ²=5.858, P<0.05). There were 8 patients in the canalith repositioning group showed changes of BBPV types after treatment, while only 1 patient in the reposition plus drug treatment group showed lesion changes. The difference was statistically significant (χ²=4.061, P<0.05). After 28 days of the treatment, the recovery rate and the total effective power of the two groups was 100%, respectively. There is no statistical difference in the total effective rate between the two groups. After 3 months follow-up, 2 patients in the canalith repositioning group (6.25%) and in the reposition plus drug treatment group (6.67%) showed BBPV recurrence, and no significant difference in the recurrence rate was found between the two groups (P>0.05). Conclusion:The repositioning maneuver is the preferred method for treating HSC BPPV. Canalith reposition maneuver plus medication has no obvious effect on the recovery rate and the recurrence rate, it only increases the effective rate and reduces the changes of the BBPV types.

Genetic and audiological characters of a Chinese family with non-syndromic hereditary hearing loss / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the phenotype and genetic characters of a Chinese family with an autosomal-dominant inherited high-frequency sensorineural hearing loss.@*METHOD@#A Chinese pedigree associated with an autosomal-dominant inherited high-frequency sensorineural hearing loss was investigated. After obtaining informed consent from all study participants medical and audiological examination to rule out any syndromic hearing impairment. Application of microsatellite markers on DFNA 21 loci preliminary screening of 23 genes, data were analyzed by linkage analysis.@*RESULT@#Proband of the family had been diagnosed with high-frequency sensorineural hearing loss. A Chinese family SX-H043 with non-syndromic hearing loss were ascertained. This Chinese family with late onset hearing impairment spanned four generations and comprised 43 members. The mode of inheritance of the families should be autosomal dominant according to the pedigree. Hearing impairment of affected members in family SX-H043 occurred 25 to 50 years descending audiograms. Whole frequencies became involved with increasing age.@*CONCLUSION@#A Chinese family with late-onset high-frequency sensorineural hearing loss were clinically studied. Positive sites were not found in the known deafness loci screening. The information should facilitate future gene scan and linkage analyses for novel relative genes contributing to high-frequency sensorineural hearing loss.

Diagnosis, treatment and medical evaluation of head and neck tumors in aircrew / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To sum up the experiences of diagnosis, treatment and medical evaluation of head and neck tumors in aircrew.@*METHOD@#Sixty-seven cases of pilot patients with head and neck tumors in our hospital since September in 1979 to July in 2009 were retrospective analyzed in the study.@*RESULT@#Among 44 aircrew with benign head and neck tumors there were 37 cases continued their flying jobs and 7 cases were permanently grounded; whereas in 23 aircrew with malignant tumors there were 6 cases qualified for flight and 17 patients unqualified.@*CONCLUSION@#Benign or malignant of the head and neck neoplasm in the pilots are not the exclusive basis for their medical assessment. Tumor nature, location, efficacy of treatment and the impact on the function of their body should be considered as making the flight medical evaluation for the aircrew with head and neck tumors. Early diagnosis and treatment of head and neck tumors in aircrew are very important for reducing the rate of grounded.

Characteristics of audiology and clinical genetics of a Chinese family with the DFNA5 genetic hearing loss / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To analysis the characteristics of audiology and clinical genetics of a Chinese family with the DFNA5 genetic hearing loss in detail.@*METHOD@#A detailed family history and clinical data were collected. The Chinese pedigree is an autosomal-dominant inherited hearing loss. The data of audiological examination about genetic characteristics was analysed. The relationship between the hearing-impaired of this family and age was contrasted.@*RESULT@#This Chinese family spanned five generations and comprised 42 members. The mode of inheritance of the families should be autosomal dominant according to the pedigree. Pure-tone audiograms showed a so-called Z shape curve. The hearing loss is sensorineural, progressive and beginning at the high frequencies. The audiograms were fairly symmetric. Whole frequencies became involved with increasing age.@*CONCLUSION@#The Chinese family with the DFNA5 mutation was an autosomal dominant pedigree. In this family, non-syndromic symmetric hearing impairment was severest at the high frequencies early, and gradually accumulated all frequencies of hearing. A mutation in DFNA5 leads to a type of hearing loss that closely resembles the frequently observed age-related hearing impairment. It should take into account DFNA5 mutation which the audiogram of a genetic hearing impaired has the same feature.

Preliminary study on diplopore puncture of tympanum and intratympanic administration for management of acute secretory otitis media / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To evaluate the therapeutical effects of diplopore puncture of tympanum and intratympanic administration (DPTIA) on patients with acute secretory otitis media (ASOM).@*METHOD@#One hundred and forty-one cases with ASOM were divided into two groups randomly, with 69 cases (80 ears) in group A (experimental group) and 72 cases (84 ears) in group B (control group). Group A was treated with DPTIA combined with medication, group B was treated with haplopore puncture of tympanum combined with medication. All patients accepted 1 to 3 courses of treatment, and were observed during the period of treatment and 3 months after treatment.@*RESULT@#The factors (including gender, age, side of ailing ear, course of disease, air-bone gap in the pure tone average, and acoustic immittance type in ailing ear) which may impact the prognosis were matched in two groups prior treatment (P>0.05). While there was a significant difference in the cure rate and the total effective rate respectively between two groups after treatment (P<0.05). No adverse reaction or complication was seen.@*CONCLUSION@#DPTIA is a safe, reliable and effective way to manage patients with ASOM.

Preliminary study on diplopore puncture of tympanum and intratympanic administration for management of acute secretory otitis media / 临床耳鼻咽喉头颈外科杂志

Objective:To evaluate the therapeutical effects of diplopore puncture of tympanum and intratympanic administration(DPTIA) on patients with acute secretory otitis media(ASOM).Method:One hundred and forty -one cases with ASOM were divided into two groups randomly,with 69 cases(80 ears) in group A(experimental group) and 72 cases(84 ears) in group B(control group).Group A was treated with DPTIA combined with medication, group B was treated with haplopore puncture of tympanum combined with medication. All patients accepted 1 to 3 courses of treament,and were observed during the period of treatment and 3 months after treatment.Result:The factors (including gender, age, side of ailing ear, course of disease, air-bone gap in the pure tone average,and acoustic immitance type in ailing ear) which may impact the prognosis were matched in two groups prior treatment(P＞0.05). While there was a significant difference in the cure rate and the total effective rate respectively between two groups after treatment(P＜0.05).No adverse reaction or complication was seen.Conclusion:DPTIA is a safe, reliable and effective way to manage patients with ASOM.

Diagnosis, treatment and medical evaluation of sinusitis and nasal polyp in aircrew / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To sum up the experiences of diagnosis, treatment and medical evaluation of sinusitis and nasal polyp in aircrew.@*METHOD@#Ninety three aircrew with sinusitis and nasal polyp were included in the study.@*RESULT@#There were 11 cases with acute sinusitis and 82 cases with chronic sinusitis and nasal polyp. Of the 82 cases, there were 46 cases in class I (including 39 cases with symptoms and signs on ground in Ia, 7 cases only with signs in Ib), 36 cases in class II (no symptoms on ground but with symptoms of secondary barotraumas in flight, including 14 cases with secondary barosinusitis in IIa, 13 cases with secondary barotrauma in IIb, 9 cases with secondary barosinusitis and barotrauma in IIc ). Of the 82 cases, there were 24 cases in 1 stage of type I, 38 cases in 2 stage of type I, 7 cases in 3 stage of type I, 2 cases in 1 stage of type II, 6 cases in 2 stage of type II, 3 cases in 3 stage of type II, 2 cases in type III. Eighty four cases continued their flying jobs and 9 cases were permanently grounded.@*CONCLUSION@#Flying safe can be endangered by sinusitis and nasal polyp alone or with its secondary barotraumas. Chronic sinusitis and nasal polyp complicated with barotraumas are important causation for medical grounding. The aircrew with sinusitis and nasal polyp will be allowed to continue their flying jobs only after getting well curative effect and normal gas pressures of ear and nasal sinus.

The Application of Vestibular Functional Test in the Diagnosis and Evaluation of Flight Illusion in Pilots / 听力学及言语疾病杂志

0.05). ②Among 30 pilots with abnormal vestibular functions,19 were permanently grounded and 11 were permitted to return their flying station. 36 pilots returned to fly in 45 cases with normal vestibular functions. The permanently grounded rate had significant differences between the two groups with normal and abnormal vestibular functions. (P